BENITIONSClinical Trial Intelligence

Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors

第2相 実施中(募集終了) NCT02867592

対象疾患Adrenal Cortical Carcinoma, Alveolar Soft Part Sarcoma, Central Nervous System Neoplasm, Childhood Clear Cell Sarcoma of Soft Tissue
第2相
スポンサーNational Cancer Institute (NCI)
ステータス実施中(募集終了)
参加者数109 名
介入(薬剤)Cabozantinib, Cabozantinib S-malate, Pharmacological Study
開始日2017年5月18日
完了日2021年6月30日
結果公開日2022年11月28日

概要

This phase II trial studies how well cabozantinib-s-malate works in treating younger patients with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to therapy, or are newly diagnosed. Cabozantinib-s-malate may stop the growth of tumor cells by blocking some of the enzymes needed for tumor growth and tumor blood vessel growth.

Objective Response (Non-Osteosarcoma Strata)

Up to the first 6 cycles of therapy · Percentage of patients

Ewing's Sarcoma0 Percentage of patients
Rhabdomyosarcoma0 Percentage of patients
Non-Rhabdomyosarcoma Soft Tissue Sarcoma0 Percentage of patients
Wilms Tumor0 Percentage of patients
Rare Tumors13.04 Percentage of patients

Objective Response (Osteosarcoma Stratum)

Up to the first 6 cycles of therapy. · Percentage of patients

Osteosarcoma35.18 Percentage of patients

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