Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors
第2相
実施中(募集終了)
NCT02867592
| 対象疾患 | Adrenal Cortical Carcinoma, Alveolar Soft Part Sarcoma, Central Nervous System Neoplasm, Childhood Clear Cell Sarcoma of Soft Tissue |
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| 相 | 第2相 |
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| スポンサー | National Cancer Institute (NCI) |
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| ステータス | 実施中(募集終了) |
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| 参加者数 | 109 名 |
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| 介入(薬剤) | Cabozantinib, Cabozantinib S-malate, Pharmacological Study |
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| 開始日 | 2017年5月18日 |
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| 完了日 | 2021年6月30日 |
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| 結果公開日 | 2022年11月28日 |
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概要
This phase II trial studies how well cabozantinib-s-malate works in treating younger patients with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to therapy, or are newly diagnosed. Cabozantinib-s-malate may stop the growth of tumor cells by blocking some of the enzymes needed for tumor growth and tumor blood vessel growth.
Objective Response (Non-Osteosarcoma Strata)
Up to the first 6 cycles of therapy · Percentage of patients
| Ewing's Sarcoma | 0 Percentage of patients |
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| Rhabdomyosarcoma | 0 Percentage of patients |
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| Non-Rhabdomyosarcoma Soft Tissue Sarcoma | 0 Percentage of patients |
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| Wilms Tumor | 0 Percentage of patients |
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| Rare Tumors | 13.04 Percentage of patients |
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Objective Response (Osteosarcoma Stratum)
Up to the first 6 cycles of therapy. · Percentage of patients
| Osteosarcoma | 35.18 Percentage of patients |
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