BENITIONSClinical Trial Intelligence

Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors

Phase 2 Active, not recruiting NCT02867592

ConditionAdrenal Cortical Carcinoma, Alveolar Soft Part Sarcoma, Central Nervous System Neoplasm, Childhood Clear Cell Sarcoma of Soft Tissue
PhasePhase 2
SponsorNational Cancer Institute (NCI)
StatusActive, not recruiting
Enrollment109 participants
InterventionsCabozantinib, Cabozantinib S-malate, Pharmacological Study
Start dateMay 18, 2017
Completion dateJun 30, 2021
Results postedNov 28, 2022

Summary

This phase II trial studies how well cabozantinib-s-malate works in treating younger patients with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to therapy, or are newly diagnosed. Cabozantinib-s-malate may stop the growth of tumor cells by blocking some of the enzymes needed for tumor growth and tumor blood vessel growth.

Objective Response (Non-Osteosarcoma Strata)

Up to the first 6 cycles of therapy · Percentage of patients

Ewing's Sarcoma0 Percentage of patients
Rhabdomyosarcoma0 Percentage of patients
Non-Rhabdomyosarcoma Soft Tissue Sarcoma0 Percentage of patients
Wilms Tumor0 Percentage of patients
Rare Tumors13.04 Percentage of patients

Objective Response (Osteosarcoma Stratum)

Up to the first 6 cycles of therapy. · Percentage of patients

Osteosarcoma35.18 Percentage of patients

Open in BENITIONS View on ClinicalTrials.gov

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This page summarises publicly available data from ClinicalTrials.gov. It is not medical advice and not investment advice. Always consult a qualified healthcare professional.