Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors
Phase 2
Active, not recruiting
NCT02867592
| Condition | Adrenal Cortical Carcinoma, Alveolar Soft Part Sarcoma, Central Nervous System Neoplasm, Childhood Clear Cell Sarcoma of Soft Tissue |
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| Phase | Phase 2 |
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| Sponsor | National Cancer Institute (NCI) |
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| Status | Active, not recruiting |
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| Enrollment | 109 participants |
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| Interventions | Cabozantinib, Cabozantinib S-malate, Pharmacological Study |
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| Start date | May 18, 2017 |
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| Completion date | Jun 30, 2021 |
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| Results posted | Nov 28, 2022 |
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Summary
This phase II trial studies how well cabozantinib-s-malate works in treating younger patients with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to therapy, or are newly diagnosed. Cabozantinib-s-malate may stop the growth of tumor cells by blocking some of the enzymes needed for tumor growth and tumor blood vessel growth.
Objective Response (Non-Osteosarcoma Strata)
Up to the first 6 cycles of therapy · Percentage of patients
| Ewing's Sarcoma | 0 Percentage of patients |
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| Rhabdomyosarcoma | 0 Percentage of patients |
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| Non-Rhabdomyosarcoma Soft Tissue Sarcoma | 0 Percentage of patients |
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| Wilms Tumor | 0 Percentage of patients |
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| Rare Tumors | 13.04 Percentage of patients |
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Objective Response (Osteosarcoma Stratum)
Up to the first 6 cycles of therapy. · Percentage of patients
| Osteosarcoma | 35.18 Percentage of patients |
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Open in BENITIONS
View on ClinicalTrials.gov
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