BENITIONSClinical Trial Intelligence

Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors

2상 진행 중(모집 완료) NCT02867592

대상 질환Adrenal Cortical Carcinoma, Alveolar Soft Part Sarcoma, Central Nervous System Neoplasm, Childhood Clear Cell Sarcoma of Soft Tissue
임상 단계2상
스폰서National Cancer Institute (NCI)
상태진행 중(모집 완료)
참여자 수109 명
중재(약물)Cabozantinib, Cabozantinib S-malate, Pharmacological Study
시작일2017년 5월 18일
완료일2021년 6월 30일
결과 공개일2022년 11월 28일

요약

This phase II trial studies how well cabozantinib-s-malate works in treating younger patients with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to therapy, or are newly diagnosed. Cabozantinib-s-malate may stop the growth of tumor cells by blocking some of the enzymes needed for tumor growth and tumor blood vessel growth.

Objective Response (Non-Osteosarcoma Strata)

Up to the first 6 cycles of therapy · Percentage of patients

Ewing's Sarcoma0 Percentage of patients
Rhabdomyosarcoma0 Percentage of patients
Non-Rhabdomyosarcoma Soft Tissue Sarcoma0 Percentage of patients
Wilms Tumor0 Percentage of patients
Rare Tumors13.04 Percentage of patients

Objective Response (Osteosarcoma Stratum)

Up to the first 6 cycles of therapy. · Percentage of patients

Osteosarcoma35.18 Percentage of patients

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