Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors
Фаза 2
Идёт, набор закрыт
NCT02867592
| Заболевание | Adrenal Cortical Carcinoma, Alveolar Soft Part Sarcoma, Central Nervous System Neoplasm, Childhood Clear Cell Sarcoma of Soft Tissue |
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| Фаза | Фаза 2 |
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| Спонсор | National Cancer Institute (NCI) |
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| Статус | Идёт, набор закрыт |
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| Участники | 109 участн. |
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| Вмешательство | Cabozantinib, Cabozantinib S-malate, Pharmacological Study |
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| Дата начала | 18.05.2017 |
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| Дата завершения | 30.06.2021 |
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| Публикация результатов | 28.11.2022 |
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Кратко
This phase II trial studies how well cabozantinib-s-malate works in treating younger patients with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to therapy, or are newly diagnosed. Cabozantinib-s-malate may stop the growth of tumor cells by blocking some of the enzymes needed for tumor growth and tumor blood vessel growth.
Objective Response (Non-Osteosarcoma Strata)
Up to the first 6 cycles of therapy · Percentage of patients
| Ewing's Sarcoma | 0 Percentage of patients |
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| Rhabdomyosarcoma | 0 Percentage of patients |
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| Non-Rhabdomyosarcoma Soft Tissue Sarcoma | 0 Percentage of patients |
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| Wilms Tumor | 0 Percentage of patients |
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| Rare Tumors | 13.04 Percentage of patients |
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Objective Response (Osteosarcoma Stratum)
Up to the first 6 cycles of therapy. · Percentage of patients
| Osteosarcoma | 35.18 Percentage of patients |
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