Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)
2期
已完成
NCT06482112
| 适应症 | Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-alcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease, Liver Disease |
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| 分期 | 2期 |
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| 申办方 | Merck Sharp & Dohme LLC |
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| 状态 | 已完成 |
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| 受试者人数 | 124 人 |
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| 干预(药物) | Efinopegdutide |
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| 开始日期 | 2024年7月29日 |
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| 完成日期 | 2025年6月27日 |
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| 结果公布日 | 2026年6月1日 |
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摘要
This study will evaluate the effect of efinopegdutide administration once every 2 weeks (Q2W) versus once weekly (Q1W) on mean relative reduction from baseline in liver fat content (LFC) after 28 weeks, as well as the safety and tolerability of the different regimens of efinopegdutide.
Mean Relative Reduction From Baseline in Liver Fat Content at Week 28
Baseline and Week 28 · Percent Reduction
| Efinopegdutide Q1W 10 mg | 67.8 Percent Reduction |
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| Efinopegdutide Q2W 10 mg | 54.4 Percent Reduction |
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| Efinopegdutide Q2W 15 mg | 42.1 Percent Reduction |
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Percentage of Participants Who Experienced an Adverse Event (AE)
Up to Week 32 · Percentage of participants
| Efinopegdutide Q1W 10 mg | 83.3 Percentage of participants |
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| Efinopegdutide Q2W 10 mg | 82.1 Percentage of participants |
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| Efinopegdutide Q2W 15 mg | 85.7 Percentage of participants |
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Percentage of Participants Who Discontinued Study Intervention Due to an AE
Up to Week 28 · Percentage of participants
| Efinopegdutide Q1W 10 mg | 7.1 Percentage of participants |
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| Efinopegdutide Q2W 10 mg | 5.1 Percentage of participants |
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| Efinopegdutide Q2W 15 mg | 9.5 Percentage of participants |
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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。