BENITIONSClinical Trial Intelligence

Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)

2期 已完成 NCT06482112

适应症Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-alcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease, Liver Disease
分期2期
申办方Merck Sharp & Dohme LLC
状态已完成
受试者人数124 人
干预(药物)Efinopegdutide
开始日期2024年7月29日
完成日期2025年6月27日
结果公布日2026年6月1日

摘要

This study will evaluate the effect of efinopegdutide administration once every 2 weeks (Q2W) versus once weekly (Q1W) on mean relative reduction from baseline in liver fat content (LFC) after 28 weeks, as well as the safety and tolerability of the different regimens of efinopegdutide.

Mean Relative Reduction From Baseline in Liver Fat Content at Week 28

Baseline and Week 28 · Percent Reduction

Efinopegdutide Q1W 10 mg67.8 Percent Reduction
Efinopegdutide Q2W 10 mg54.4 Percent Reduction
Efinopegdutide Q2W 15 mg42.1 Percent Reduction

Percentage of Participants Who Experienced an Adverse Event (AE)

Up to Week 32 · Percentage of participants

Efinopegdutide Q1W 10 mg83.3 Percentage of participants
Efinopegdutide Q2W 10 mg82.1 Percentage of participants
Efinopegdutide Q2W 15 mg85.7 Percentage of participants

Percentage of Participants Who Discontinued Study Intervention Due to an AE

Up to Week 28 · Percentage of participants

Efinopegdutide Q1W 10 mg7.1 Percentage of participants
Efinopegdutide Q2W 10 mg5.1 Percentage of participants
Efinopegdutide Q2W 15 mg9.5 Percentage of participants

在 BENITIONS 中查看 查看 ClinicalTrials.gov 原文

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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。