Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)
第2相
完了
NCT06482112
| 対象疾患 | Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-alcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease, Liver Disease |
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| 相 | 第2相 |
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| スポンサー | Merck Sharp & Dohme LLC |
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| ステータス | 完了 |
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| 参加者数 | 124 名 |
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| 介入(薬剤) | Efinopegdutide |
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| 開始日 | 2024年7月29日 |
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| 完了日 | 2025年6月27日 |
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| 結果公開日 | 2026年6月1日 |
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概要
This study will evaluate the effect of efinopegdutide administration once every 2 weeks (Q2W) versus once weekly (Q1W) on mean relative reduction from baseline in liver fat content (LFC) after 28 weeks, as well as the safety and tolerability of the different regimens of efinopegdutide.
Mean Relative Reduction From Baseline in Liver Fat Content at Week 28
Baseline and Week 28 · Percent Reduction
| Efinopegdutide Q1W 10 mg | 67.8 Percent Reduction |
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| Efinopegdutide Q2W 10 mg | 54.4 Percent Reduction |
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| Efinopegdutide Q2W 15 mg | 42.1 Percent Reduction |
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Percentage of Participants Who Experienced an Adverse Event (AE)
Up to Week 32 · Percentage of participants
| Efinopegdutide Q1W 10 mg | 83.3 Percentage of participants |
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| Efinopegdutide Q2W 10 mg | 82.1 Percentage of participants |
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| Efinopegdutide Q2W 15 mg | 85.7 Percentage of participants |
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Percentage of Participants Who Discontinued Study Intervention Due to an AE
Up to Week 28 · Percentage of participants
| Efinopegdutide Q1W 10 mg | 7.1 Percentage of participants |
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| Efinopegdutide Q2W 10 mg | 5.1 Percentage of participants |
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| Efinopegdutide Q2W 15 mg | 9.5 Percentage of participants |
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このページは ClinicalTrials.gov の公開データをまとめたものです。医学的助言ではなく、投資助言でもありません。必ず専門医にご相談ください。