BENITIONSClinical Trial Intelligence

Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)

2상 완료 NCT06482112

대상 질환Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-alcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease, Liver Disease
임상 단계2상
스폰서Merck Sharp & Dohme LLC
상태완료
참여자 수124 명
중재(약물)Efinopegdutide
시작일2024년 7월 29일
완료일2025년 6월 27일
결과 공개일2026년 6월 1일

요약

This study will evaluate the effect of efinopegdutide administration once every 2 weeks (Q2W) versus once weekly (Q1W) on mean relative reduction from baseline in liver fat content (LFC) after 28 weeks, as well as the safety and tolerability of the different regimens of efinopegdutide.

Mean Relative Reduction From Baseline in Liver Fat Content at Week 28

Baseline and Week 28 · Percent Reduction

Efinopegdutide Q1W 10 mg67.8 Percent Reduction
Efinopegdutide Q2W 10 mg54.4 Percent Reduction
Efinopegdutide Q2W 15 mg42.1 Percent Reduction

Percentage of Participants Who Experienced an Adverse Event (AE)

Up to Week 32 · Percentage of participants

Efinopegdutide Q1W 10 mg83.3 Percentage of participants
Efinopegdutide Q2W 10 mg82.1 Percentage of participants
Efinopegdutide Q2W 15 mg85.7 Percentage of participants

Percentage of Participants Who Discontinued Study Intervention Due to an AE

Up to Week 28 · Percentage of participants

Efinopegdutide Q1W 10 mg7.1 Percentage of participants
Efinopegdutide Q2W 10 mg5.1 Percentage of participants
Efinopegdutide Q2W 15 mg9.5 Percentage of participants

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