Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)
Фаза 2
Завершено
NCT06482112
| Заболевание | Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-alcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease, Liver Disease |
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| Фаза | Фаза 2 |
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| Спонсор | Merck Sharp & Dohme LLC |
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| Статус | Завершено |
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| Участники | 124 участн. |
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| Вмешательство | Efinopegdutide |
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| Дата начала | 29.07.2024 |
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| Дата завершения | 27.06.2025 |
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| Публикация результатов | 1.06.2026 |
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Кратко
This study will evaluate the effect of efinopegdutide administration once every 2 weeks (Q2W) versus once weekly (Q1W) on mean relative reduction from baseline in liver fat content (LFC) after 28 weeks, as well as the safety and tolerability of the different regimens of efinopegdutide.
Mean Relative Reduction From Baseline in Liver Fat Content at Week 28
Baseline and Week 28 · Percent Reduction
| Efinopegdutide Q1W 10 mg | 67.8 Percent Reduction |
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| Efinopegdutide Q2W 10 mg | 54.4 Percent Reduction |
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| Efinopegdutide Q2W 15 mg | 42.1 Percent Reduction |
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Percentage of Participants Who Experienced an Adverse Event (AE)
Up to Week 32 · Percentage of participants
| Efinopegdutide Q1W 10 mg | 83.3 Percentage of participants |
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| Efinopegdutide Q2W 10 mg | 82.1 Percentage of participants |
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| Efinopegdutide Q2W 15 mg | 85.7 Percentage of participants |
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Percentage of Participants Who Discontinued Study Intervention Due to an AE
Up to Week 28 · Percentage of participants
| Efinopegdutide Q1W 10 mg | 7.1 Percentage of participants |
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| Efinopegdutide Q2W 10 mg | 5.1 Percentage of participants |
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| Efinopegdutide Q2W 15 mg | 9.5 Percentage of participants |
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