BENITIONSClinical Trial Intelligence

Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)

Фаза 2 Завершено NCT06482112

ЗаболеваниеMetabolic Dysfunction-Associated Steatotic Liver Disease, Non-alcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease, Liver Disease
ФазаФаза 2
СпонсорMerck Sharp & Dohme LLC
СтатусЗавершено
Участники124 участн.
ВмешательствоEfinopegdutide
Дата начала29.07.2024
Дата завершения27.06.2025
Публикация результатов1.06.2026

Кратко

This study will evaluate the effect of efinopegdutide administration once every 2 weeks (Q2W) versus once weekly (Q1W) on mean relative reduction from baseline in liver fat content (LFC) after 28 weeks, as well as the safety and tolerability of the different regimens of efinopegdutide.

Mean Relative Reduction From Baseline in Liver Fat Content at Week 28

Baseline and Week 28 · Percent Reduction

Efinopegdutide Q1W 10 mg67.8 Percent Reduction
Efinopegdutide Q2W 10 mg54.4 Percent Reduction
Efinopegdutide Q2W 15 mg42.1 Percent Reduction

Percentage of Participants Who Experienced an Adverse Event (AE)

Up to Week 32 · Percentage of participants

Efinopegdutide Q1W 10 mg83.3 Percentage of participants
Efinopegdutide Q2W 10 mg82.1 Percentage of participants
Efinopegdutide Q2W 15 mg85.7 Percentage of participants

Percentage of Participants Who Discontinued Study Intervention Due to an AE

Up to Week 28 · Percentage of participants

Efinopegdutide Q1W 10 mg7.1 Percentage of participants
Efinopegdutide Q2W 10 mg5.1 Percentage of participants
Efinopegdutide Q2W 15 mg9.5 Percentage of participants

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