Premedication to Reduce Amivantamab Associated Infusion Related Reactions
| 适应症 | Carcinoma, Non-Small-Cell Lung |
|---|---|
| 分期 | 2期 |
| 申办方 | Janssen Research & Development, LLC |
| 状态 | 进行中（已停止招募） |
| 受试者人数 | 68 人 |
| 干预（药物） | Dexamethasone, Montelukast, Methotrexate, Amivantamab, Lazertinib |
| 开始日期 | 2023年5月18日 |
| 完成日期 | 2024年3月29日 |
| 结果公布日 | 2025年10月20日 |
摘要
The purpose of the study is to separately assess the potential of dexamethasone, montelukast and methotrexate administration, prior to amivantamab infusion given through a needle in the vein, to decrease the incidence and/or severity of first-dose infusion related reactions.
Percentage of Participants With Infusion-related Reactions (IRRs) at Cycle 1 Day 1
| Cohort A: Dexamethasone 4 Milligrams (mg) | 83.3 Percentage of participants |
|---|---|
| Cohort A2: Dexamethasone 8 mg | 22.5 Percentage of participants |
| Cohort B: Montelukast 10 mg | 66.7 Percentage of participants |
| Cohort C: Methotrexate 25 mg | 83.3 Percentage of participants |
在 BENITIONS 中查看 查看 ClinicalTrials.gov 原文
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