Premedication to Reduce Amivantamab Associated Infusion Related Reactions
| Condition | Carcinoma, Non-Small-Cell Lung |
|---|---|
| Phase | Phase 2 |
| Sponsor | Janssen Research & Development, LLC |
| Status | Active, not recruiting |
| Enrollment | 68 participants |
| Interventions | Dexamethasone, Montelukast, Methotrexate, Amivantamab, Lazertinib |
| Start date | May 18, 2023 |
| Completion date | Mar 29, 2024 |
| Results posted | Oct 20, 2025 |
Summary
The purpose of the study is to separately assess the potential of dexamethasone, montelukast and methotrexate administration, prior to amivantamab infusion given through a needle in the vein, to decrease the incidence and/or severity of first-dose infusion related reactions.
Percentage of Participants With Infusion-related Reactions (IRRs) at Cycle 1 Day 1
| Cohort A: Dexamethasone 4 Milligrams (mg) | 83.3 Percentage of participants |
|---|---|
| Cohort A2: Dexamethasone 8 mg | 22.5 Percentage of participants |
| Cohort B: Montelukast 10 mg | 66.7 Percentage of participants |
| Cohort C: Methotrexate 25 mg | 83.3 Percentage of participants |
Open in BENITIONS View on ClinicalTrials.gov
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