Premedication to Reduce Amivantamab Associated Infusion Related Reactions
| Заболевание | Carcinoma, Non-Small-Cell Lung |
|---|---|
| Фаза | Фаза 2 |
| Спонсор | Janssen Research & Development, LLC |
| Статус | Идёт, набор закрыт |
| Участники | 68 участн. |
| Вмешательство | Dexamethasone, Montelukast, Methotrexate, Amivantamab, Lazertinib |
| Дата начала | 18.05.2023 |
| Дата завершения | 29.03.2024 |
| Публикация результатов | 20.10.2025 |
Кратко
The purpose of the study is to separately assess the potential of dexamethasone, montelukast and methotrexate administration, prior to amivantamab infusion given through a needle in the vein, to decrease the incidence and/or severity of first-dose infusion related reactions.
Percentage of Participants With Infusion-related Reactions (IRRs) at Cycle 1 Day 1
| Cohort A: Dexamethasone 4 Milligrams (mg) | 83.3 Percentage of participants |
|---|---|
| Cohort A2: Dexamethasone 8 mg | 22.5 Percentage of participants |
| Cohort B: Montelukast 10 mg | 66.7 Percentage of participants |
| Cohort C: Methotrexate 25 mg | 83.3 Percentage of participants |
Открыть в BENITIONS Открыть на ClinicalTrials.gov
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