A Global Study to Assess the Effects of Osimertinib Following Chemoradiation in Patients With Stage III Unresectable Non-small Cell Lung Cancer (LAURA)
Phase 3
Active, not recruiting
NCT03521154
| Condition | Non Small Cell Lung Cancer |
|---|
| Phase | Phase 3 |
|---|
| Sponsor | AstraZeneca |
|---|
| Status | Active, not recruiting |
|---|
| Enrollment | 216 participants |
|---|
| Interventions | Osimertinib 80mg/40mg, Placebo Osimertinib 80mg/40mg |
|---|
| Start date | Jul 19, 2018 |
|---|
| Completion date | Jan 5, 2024 |
|---|
| Results posted | Apr 3, 2025 |
|---|
Summary
A global study to assess the efficacy and safety of osimertinib following chemoradiation in patients with stage III unresectable Epidermal Growth Factor Receptor Mutation Positive non-small cell lung cancer
Progression-free Survival (PFS) by Blinded Independent Central Review (BICR)
Every 8 weeks for first 48 weeks, then every 12 weeks until BICR-confirmed radiological disease progression. Assessed up to date of DCO (05Jan24) to a maximum of approximately 63 months · Months
| Osimertinib | 39.13 Months |
|---|
| Placebo | 5.55 Months |
|---|
| p-value | <0.001 |
| Hazard Ratio (HR) | 0.16 (95% CI 0.10–0.24) |
Open in BENITIONS
View on ClinicalTrials.gov
Other trials for this condition
All trials
This page summarises publicly available data from ClinicalTrials.gov. It is not medical advice and not investment advice. Always consult a qualified healthcare professional.