Exploratory Open Label Study for Development of a Method To Detect Dendritic Cells

N/A Completed NCT05482867

Summary

This is a proof-of-concept study designed to confirm that human phagocytic cells can be labeled with the near-infrared dye indocyanine green (ICG) and the presence of the labeled cells 48 hours later in cerebral cortex can be inferred using near infrared spectroscopy (NIRS).

Treatment Emergent Adverse Events (TEAEs)

Dosing (Day 0) through Telephone Follow-up (Day 16) · participants

Electrocardiogram Results

Screening, Day 0 and Day 2 · participants

Mean ICG Concentrations

Post Dosing time points: at 60 mins, 120 mins, 150 mins, 240 mins and 48 hours · ng/mLs

Open in BENITIONS View on ClinicalTrials.gov

Other trials for this condition

• Brain Energy for Amyloid Transformation in Alzheimer's Disease Study — Wake Forest University Health Sciences
• Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss — Eli Lilly and Company
• Using a Wireless Controller to Deliver a Lighting Intervention to Persons With Dementia — Icahn School of Medicine at Mount Sinai
• Deprescribing in Patients Living With Dementia With Caregiver and Provider Nudges — Brigham and Women's Hospital
• Technology and Family Thriving Study — University of California, Santa Barbara
• Community-based Brain Health Program to Address Dementia Risk — Posit Science Corporation

All trials