Exploratory Open Label Study for Development of a Method To Detect Dendritic Cells
Не применимо
Завершено
NCT05482867
| Заболевание | Probable Alzheimer's Disease |
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| Фаза | Не применимо |
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| Спонсор | MindImmune Therapeutics, Inc. |
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| Статус | Завершено |
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| Участники | 46 участн. |
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| Дата начала | 28.11.2022 |
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| Дата завершения | 7.08.2024 |
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| Публикация результатов | 8.07.2026 |
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Кратко
This is a proof-of-concept study designed to confirm that human phagocytic cells can be labeled with the near-infrared dye indocyanine green (ICG) and the presence of the labeled cells 48 hours later in cerebral cortex can be inferred using near infrared spectroscopy (NIRS).
Treatment Emergent Adverse Events (TEAEs)
Dosing (Day 0) through Telephone Follow-up (Day 16) · participants
| Cohort 1 | 3 participants |
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| Cohort 2 | 6 participants |
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| Cohort 2A | 1 participants |
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| Cohort 3A, | 3 participants |
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| Cohort 3 | 7 participants |
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| Cohort4, | 2 participants |
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Electrocardiogram Results
Screening, Day 0 and Day 2 · participants
| Cohort 1 | 2 participants |
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| Cohort 2 | 2 participants |
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| Cohort 2A | 0 participants |
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| Cohort 3A, | 1 participants |
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| Cohort 3 | 4 participants |
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| Cohort 4, | 1 participants |
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Mean ICG Concentrations
Post Dosing time points: at 60 mins, 120 mins, 150 mins, 240 mins and 48 hours · ng/mLs
| Cohort 1 | 2743.76 ng/mLs |
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| Cohort 2 | 3388.33 ng/mLs |
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| Cohort 3 | 4377.45 ng/mLs |
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| Cohort 2A | 2591.10 ng/mLs |
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| Cohort 3A, | 5032.67 ng/mLs |
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| Cohort4, | 3181.98 ng/mLs |
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Открыть в BENITIONS
Открыть на ClinicalTrials.gov
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