BENITIONSClinical Trial Intelligence

Subsequent Line Gemcitabine and Nivolumab in Treating Participants With Metastatic Small Cell Lung Cancer

2상 조기 종료 NCT03662074

대상 질환Small Cell Lung Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8
임상 단계2상
스폰서Wake Forest University Health Sciences
상태조기 종료
참여자 수14 명
중재(약물)Gemcitabine, Nivolumab
시작일2018년 11월 7일
완료일2020년 10월 7일
결과 공개일2021년 11월 12일

요약

This phase II pilot trial studies how well gemcitabine and nivolumab work in treating participants with small cell lung cancer that has spread to other parts of the body after other treatments have failed. Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as nivolumab, may interfere with the ability of tumor cells to grow and spread. Giving second-line gemcitabine and nivolumab may work better in treating participants with small cell lung cancer.

Number of Participants With Positive Responses to Therapy Per Response Evaluation Criteria in Solid Tumors (RECIST)

Up to 8 weeks · Participants

Treatment (Gemcitabine, Nivolumab)1 Participants
Treatment (Gemcitabine, Nivolumab)11 Participants
Treatment (Gemcitabine, Nivolumab)2 Participants

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