BENITIONSClinical Trial Intelligence

Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors

3상 진행 중(모집 완료) NCT03375320

대상 질환Functioning Pancreatic Neuroendocrine Tumor, Intermediate Grade Lung Neuroendocrine Neoplasm, Locally Advanced Digestive System Neuroendocrine Neoplasm, Locally Advanced Digestive System Neuroendocrine Tumor G1
임상 단계3상
스폰서National Cancer Institute (NCI)
상태진행 중(모집 완료)
참여자 수298 명
중재(약물)Biospecimen Collection, Cabozantinib S-malate, Computed Tomography, Magnetic Resonance Imaging, Placebo Administration
시작일2018년 10월 26일
완료일2023년 8월 23일
결과 공개일2024년 10월 16일

요약

This phase III trial studies cabozantinib to see how well it works compared with placebo in treating patients with neuroendocrine or carcinoid tumors that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Cabozantinib is a chemotherapy drug known as a tyrosine kinase inhibitor, and it targets specific tyrosine kinase receptors, that when blocked, may slow tumor growth.

Progression-free Survival (PFS)

36 months · months

Arm Ia (Cabozantinib S-malate, Extra-pancreatic NET Cohort [epNET])8.4 months
Arm IIa (Placebo, Extra-pancreatic NET Cohort [epNET])3.9 months
Arm Ib (Cabozantinib S-malate, Pancreatic NET Cohort [pNET])13.8 months
Arm IIb (Placebo, Pancreatic NET Cohort [pNET])4.4 months
p-value<0.0001

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