Subsequent Line Gemcitabine and Nivolumab in Treating Participants With Metastatic Small Cell Lung Cancer
| Condition | Small Cell Lung Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8 |
|---|---|
| Phase | Phase 2 |
| Sponsor | Wake Forest University Health Sciences |
| Status | Terminated |
| Enrollment | 14 participants |
| Interventions | Gemcitabine, Nivolumab |
| Start date | Nov 7, 2018 |
| Completion date | Oct 7, 2020 |
| Results posted | Nov 12, 2021 |
Summary
This phase II pilot trial studies how well gemcitabine and nivolumab work in treating participants with small cell lung cancer that has spread to other parts of the body after other treatments have failed. Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as nivolumab, may interfere with the ability of tumor cells to grow and spread. Giving second-line gemcitabine and nivolumab may work better in treating participants with small cell lung cancer.
Number of Participants With Positive Responses to Therapy Per Response Evaluation Criteria in Solid Tumors (RECIST)
| Treatment (Gemcitabine, Nivolumab) | 1 Participants |
|---|---|
| Treatment (Gemcitabine, Nivolumab) | 11 Participants |
| Treatment (Gemcitabine, Nivolumab) | 2 Participants |
Open in BENITIONS View on ClinicalTrials.gov
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