BENITIONSClinical Trial Intelligence

Subsequent Line Gemcitabine and Nivolumab in Treating Participants With Metastatic Small Cell Lung Cancer

Phase 2 Terminated NCT03662074

ConditionSmall Cell Lung Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8
PhasePhase 2
SponsorWake Forest University Health Sciences
StatusTerminated
Enrollment14 participants
InterventionsGemcitabine, Nivolumab
Start dateNov 7, 2018
Completion dateOct 7, 2020
Results postedNov 12, 2021

Summary

This phase II pilot trial studies how well gemcitabine and nivolumab work in treating participants with small cell lung cancer that has spread to other parts of the body after other treatments have failed. Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as nivolumab, may interfere with the ability of tumor cells to grow and spread. Giving second-line gemcitabine and nivolumab may work better in treating participants with small cell lung cancer.

Number of Participants With Positive Responses to Therapy Per Response Evaluation Criteria in Solid Tumors (RECIST)

Up to 8 weeks · Participants

Treatment (Gemcitabine, Nivolumab)1 Participants
Treatment (Gemcitabine, Nivolumab)11 Participants
Treatment (Gemcitabine, Nivolumab)2 Participants

Open in BENITIONS View on ClinicalTrials.gov

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