Regorafenib and Durvalumab for the Treatment of High-Risk Liver Cancer
| 対象疾患 | Stage IB Hepatocellular Carcinoma AJCC v8, Stage II Hepatocellular Carcinoma AJCC v8, Stage III Hepatocellular Carcinoma AJCC v8, Stage IIIA Hepatocellular Carcinoma AJCC v8 |
|---|---|
| 相 | 第2相 |
| スポンサー | Academic and Community Cancer Research United |
| ステータス | 実施中（募集終了） |
| 参加者数 | 4 名 |
| 介入（薬剤） | Durvalumab, Regorafenib |
| 開始日 | 2023年7月1日 |
| 完了日 | 2025年12月5日 |
| 結果公開日 | 2026年7月20日 |
概要
This phase II trial tests whether regorafenib and durvalumab work to shrink tumors in patients with high-risk liver cancer. Regorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. Giving regorafenib and durvalumab may work better in treating patients with high-risk liver cancer.
Objective Response Rate (ORR) (Unconfirmed)
| Treatment (Regorafenib, Durvalumab) | 0 percentage of participants |
|---|
BENITIONS で見る ClinicalTrials.gov の原文を見る
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- A Study of Durvalumab or Tremelimumab Monotherapy, or Durvalumab in Combination With Treme — MedImmune LLC
- Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Live — National Cancer Institute (NCI)
- A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma — CStone Pharmaceuticals
- BMS-986205 and Nivolumab as First or Second Line Therapy in Treating Patients With Liver C — Edward Kim
- Study of Durvalumab and Tremelimumab as First-line Treatment in Patients With Advanced Hep — AstraZeneca
- Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Di — National Cancer Institute (NCI)