BENITIONSClinical Trial Intelligence

Accelerated rTMS for Post-Stroke Apathy

1期 已完成 NCT05878457

适应症Apathy, Stroke Sequelae, Stroke or TIA, Stroke/Brain Attack
分期1期
申办方Medical University of South Carolina
状态已完成
受试者人数21 人
干预(药物)MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System
开始日期2023年12月1日
完成日期2025年4月30日
结果公布日2026年7月10日

摘要

This pilot study will investigate the safety, feasibility, tolerability, and preliminary efficacy of accelerated high-dose repetitive transcranial magnetic stimulation (rTMS) targeting the medial prefrontal cortex (mPFC) to address apathy symptoms in individuals with chronic stroke.

Change in Apathy Symptoms, as Measured by the Lille Apathy Rating Scale (LARS) Compared to Baseline

Pre-treatment, immediately post-treatment, and at one-month follow-up · scores on a scale

Repetitive Transcranial Magnetic Stimulation-20.86 ± 8.56 scores on a scale
Repetitive Transcranial Magnetic Stimulation-23.36 ± 5.89 scores on a scale
Repetitive Transcranial Magnetic Stimulation-26.86 ± 5.04 scores on a scale

Treatment-Emergent Adverse Events and Side Effects as Assessed by Intermittent Theta Burst Stimulation Review of Systems (iTBS ROS)

Across the 3 rTMS treatment days · scores on a scale

Repetitive Transcranial Magnetic Stimulation0 ± 0 scores on a scale
Repetitive Transcranial Magnetic Stimulation1.21 ± 1.72 scores on a scale
Repetitive Transcranial Magnetic Stimulation0.71 ± 1.44 scores on a scale
Repetitive Transcranial Magnetic Stimulation0.00 ± 0.00 scores on a scale
Repetitive Transcranial Magnetic Stimulation1.21 ± 1.72 scores on a scale
Repetitive Transcranial Magnetic Stimulation0.00 ± 0.00 scores on a scale

Change in Global Cognition, as Measured by the Montreal Cognitive Assessment (MoCA) Compared to Baseline

Pre-treatment, immediately post-treatment, and at one-month follow-up · scores on a scale

Repetitive Transcranial Magnetic Stimulation24.50 ± 3.23 scores on a scale
Repetitive Transcranial Magnetic Stimulation25.00 ± 3.67 scores on a scale
Repetitive Transcranial Magnetic Stimulation25.20 ± 3.56 scores on a scale

在 BENITIONS 中查看 查看 ClinicalTrials.gov 原文

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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。