Accelerated rTMS for Post-Stroke Apathy
1期
已完成
NCT05878457
| 适应症 | Apathy, Stroke Sequelae, Stroke or TIA, Stroke/Brain Attack |
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| 分期 | 1期 |
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| 申办方 | Medical University of South Carolina |
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| 状态 | 已完成 |
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| 受试者人数 | 21 人 |
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| 干预(药物) | MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System |
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| 开始日期 | 2023年12月1日 |
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| 完成日期 | 2025年4月30日 |
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| 结果公布日 | 2026年7月10日 |
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摘要
This pilot study will investigate the safety, feasibility, tolerability, and preliminary efficacy of accelerated high-dose repetitive transcranial magnetic stimulation (rTMS) targeting the medial prefrontal cortex (mPFC) to address apathy symptoms in individuals with chronic stroke.
Change in Apathy Symptoms, as Measured by the Lille Apathy Rating Scale (LARS) Compared to Baseline
Pre-treatment, immediately post-treatment, and at one-month follow-up · scores on a scale
| Repetitive Transcranial Magnetic Stimulation | -20.86 ± 8.56 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | -23.36 ± 5.89 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | -26.86 ± 5.04 scores on a scale |
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Treatment-Emergent Adverse Events and Side Effects as Assessed by Intermittent Theta Burst Stimulation Review of Systems (iTBS ROS)
Across the 3 rTMS treatment days · scores on a scale
| Repetitive Transcranial Magnetic Stimulation | 0 ± 0 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 1.21 ± 1.72 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 0.71 ± 1.44 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 0.00 ± 0.00 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 1.21 ± 1.72 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 0.00 ± 0.00 scores on a scale |
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Change in Global Cognition, as Measured by the Montreal Cognitive Assessment (MoCA) Compared to Baseline
Pre-treatment, immediately post-treatment, and at one-month follow-up · scores on a scale
| Repetitive Transcranial Magnetic Stimulation | 24.50 ± 3.23 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 25.00 ± 3.67 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 25.20 ± 3.56 scores on a scale |
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查看 ClinicalTrials.gov 原文
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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。