Accelerated rTMS for Post-Stroke Apathy
1상
완료
NCT05878457
| 대상 질환 | Apathy, Stroke Sequelae, Stroke or TIA, Stroke/Brain Attack |
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| 임상 단계 | 1상 |
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| 스폰서 | Medical University of South Carolina |
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| 상태 | 완료 |
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| 참여자 수 | 21 명 |
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| 중재(약물) | MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System |
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| 시작일 | 2023년 12월 1일 |
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| 완료일 | 2025년 4월 30일 |
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| 결과 공개일 | 2026년 7월 10일 |
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요약
This pilot study will investigate the safety, feasibility, tolerability, and preliminary efficacy of accelerated high-dose repetitive transcranial magnetic stimulation (rTMS) targeting the medial prefrontal cortex (mPFC) to address apathy symptoms in individuals with chronic stroke.
Change in Apathy Symptoms, as Measured by the Lille Apathy Rating Scale (LARS) Compared to Baseline
Pre-treatment, immediately post-treatment, and at one-month follow-up · scores on a scale
| Repetitive Transcranial Magnetic Stimulation | -20.86 ± 8.56 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | -23.36 ± 5.89 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | -26.86 ± 5.04 scores on a scale |
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Treatment-Emergent Adverse Events and Side Effects as Assessed by Intermittent Theta Burst Stimulation Review of Systems (iTBS ROS)
Across the 3 rTMS treatment days · scores on a scale
| Repetitive Transcranial Magnetic Stimulation | 0 ± 0 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 1.21 ± 1.72 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 0.71 ± 1.44 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 0.00 ± 0.00 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 1.21 ± 1.72 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 0.00 ± 0.00 scores on a scale |
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Change in Global Cognition, as Measured by the Montreal Cognitive Assessment (MoCA) Compared to Baseline
Pre-treatment, immediately post-treatment, and at one-month follow-up · scores on a scale
| Repetitive Transcranial Magnetic Stimulation | 24.50 ± 3.23 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 25.00 ± 3.67 scores on a scale |
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| Repetitive Transcranial Magnetic Stimulation | 25.20 ± 3.56 scores on a scale |
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BENITIONS에서 보기
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