BENITIONSClinical Trial Intelligence

Accelerated rTMS for Post-Stroke Apathy

1상 완료 NCT05878457

대상 질환Apathy, Stroke Sequelae, Stroke or TIA, Stroke/Brain Attack
임상 단계1상
스폰서Medical University of South Carolina
상태완료
참여자 수21 명
중재(약물)MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System
시작일2023년 12월 1일
완료일2025년 4월 30일
결과 공개일2026년 7월 10일

요약

This pilot study will investigate the safety, feasibility, tolerability, and preliminary efficacy of accelerated high-dose repetitive transcranial magnetic stimulation (rTMS) targeting the medial prefrontal cortex (mPFC) to address apathy symptoms in individuals with chronic stroke.

Change in Apathy Symptoms, as Measured by the Lille Apathy Rating Scale (LARS) Compared to Baseline

Pre-treatment, immediately post-treatment, and at one-month follow-up · scores on a scale

Repetitive Transcranial Magnetic Stimulation-20.86 ± 8.56 scores on a scale
Repetitive Transcranial Magnetic Stimulation-23.36 ± 5.89 scores on a scale
Repetitive Transcranial Magnetic Stimulation-26.86 ± 5.04 scores on a scale

Treatment-Emergent Adverse Events and Side Effects as Assessed by Intermittent Theta Burst Stimulation Review of Systems (iTBS ROS)

Across the 3 rTMS treatment days · scores on a scale

Repetitive Transcranial Magnetic Stimulation0 ± 0 scores on a scale
Repetitive Transcranial Magnetic Stimulation1.21 ± 1.72 scores on a scale
Repetitive Transcranial Magnetic Stimulation0.71 ± 1.44 scores on a scale
Repetitive Transcranial Magnetic Stimulation0.00 ± 0.00 scores on a scale
Repetitive Transcranial Magnetic Stimulation1.21 ± 1.72 scores on a scale
Repetitive Transcranial Magnetic Stimulation0.00 ± 0.00 scores on a scale

Change in Global Cognition, as Measured by the Montreal Cognitive Assessment (MoCA) Compared to Baseline

Pre-treatment, immediately post-treatment, and at one-month follow-up · scores on a scale

Repetitive Transcranial Magnetic Stimulation24.50 ± 3.23 scores on a scale
Repetitive Transcranial Magnetic Stimulation25.00 ± 3.67 scores on a scale
Repetitive Transcranial Magnetic Stimulation25.20 ± 3.56 scores on a scale

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