BENITIONSClinical Trial Intelligence

Accelerated rTMS for Post-Stroke Apathy

第1相 完了 NCT05878457

対象疾患Apathy, Stroke Sequelae, Stroke or TIA, Stroke/Brain Attack
第1相
スポンサーMedical University of South Carolina
ステータス完了
参加者数21 名
介入(薬剤)MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System
開始日2023年12月1日
完了日2025年4月30日
結果公開日2026年7月10日

概要

This pilot study will investigate the safety, feasibility, tolerability, and preliminary efficacy of accelerated high-dose repetitive transcranial magnetic stimulation (rTMS) targeting the medial prefrontal cortex (mPFC) to address apathy symptoms in individuals with chronic stroke.

Change in Apathy Symptoms, as Measured by the Lille Apathy Rating Scale (LARS) Compared to Baseline

Pre-treatment, immediately post-treatment, and at one-month follow-up · scores on a scale

Repetitive Transcranial Magnetic Stimulation-20.86 ± 8.56 scores on a scale
Repetitive Transcranial Magnetic Stimulation-23.36 ± 5.89 scores on a scale
Repetitive Transcranial Magnetic Stimulation-26.86 ± 5.04 scores on a scale

Treatment-Emergent Adverse Events and Side Effects as Assessed by Intermittent Theta Burst Stimulation Review of Systems (iTBS ROS)

Across the 3 rTMS treatment days · scores on a scale

Repetitive Transcranial Magnetic Stimulation0 ± 0 scores on a scale
Repetitive Transcranial Magnetic Stimulation1.21 ± 1.72 scores on a scale
Repetitive Transcranial Magnetic Stimulation0.71 ± 1.44 scores on a scale
Repetitive Transcranial Magnetic Stimulation0.00 ± 0.00 scores on a scale
Repetitive Transcranial Magnetic Stimulation1.21 ± 1.72 scores on a scale
Repetitive Transcranial Magnetic Stimulation0.00 ± 0.00 scores on a scale

Change in Global Cognition, as Measured by the Montreal Cognitive Assessment (MoCA) Compared to Baseline

Pre-treatment, immediately post-treatment, and at one-month follow-up · scores on a scale

Repetitive Transcranial Magnetic Stimulation24.50 ± 3.23 scores on a scale
Repetitive Transcranial Magnetic Stimulation25.00 ± 3.67 scores on a scale
Repetitive Transcranial Magnetic Stimulation25.20 ± 3.56 scores on a scale

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