BENITIONSClinical Trial Intelligence

Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke

3期 已完成 NCT03872401

适应症Coronary Heart Disease
分期3期
申办方Amgen
状态已完成
受试者人数12,301 人
干预(药物)Evolocumab
开始日期2019年6月11日
完成日期2025年7月25日
结果公布日2026年6月25日

摘要

This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event.

Number of Participants Who Experienced Coronary Heart Disease (CHD) Death, Myocardial Infarction (MI), or Ischemic Stroke, Whichever Occurred First

From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months · Participants

Placebo Q2W443 Participants
Evolocumab 140 mg Q2W336 Participants
p-value< 0.001
Hazard Ratio (HR)0.75 (95% CI 0.65–0.86)

Number of Participants Who Experienced CHD Death, MI, Ischemic Stroke, or Any Ischemia-driven Arterial Revascularization, Whichever Occurred First

From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months · Participants

Placebo Q2W907 Participants
Evolocumab 140 mg Q2W747 Participants
p-value< 0.001
Hazard Ratio (HR)0.81 (95% CI 0.73–0.89)

在 BENITIONS 中查看 查看 ClinicalTrials.gov 原文

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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。