Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke
3期
已完成
NCT03872401
| 适应症 | Coronary Heart Disease |
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| 分期 | 3期 |
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| 申办方 | Amgen |
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| 状态 | 已完成 |
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| 受试者人数 | 12,301 人 |
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| 干预(药物) | Evolocumab |
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| 开始日期 | 2019年6月11日 |
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| 完成日期 | 2025年7月25日 |
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| 结果公布日 | 2026年6月25日 |
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摘要
This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event.
Number of Participants Who Experienced Coronary Heart Disease (CHD) Death, Myocardial Infarction (MI), or Ischemic Stroke, Whichever Occurred First
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months · Participants
| Placebo Q2W | 443 Participants |
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| Evolocumab 140 mg Q2W | 336 Participants |
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| p-value | < 0.001 |
| Hazard Ratio (HR) | 0.75 (95% CI 0.65–0.86) |
Number of Participants Who Experienced CHD Death, MI, Ischemic Stroke, or Any Ischemia-driven Arterial Revascularization, Whichever Occurred First
From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months · Participants
| Placebo Q2W | 907 Participants |
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| Evolocumab 140 mg Q2W | 747 Participants |
|---|
| p-value | < 0.001 |
| Hazard Ratio (HR) | 0.81 (95% CI 0.73–0.89) |
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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。