BENITIONSClinical Trial Intelligence

Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke

3상 완료 NCT03872401

대상 질환Coronary Heart Disease
임상 단계3상
스폰서Amgen
상태완료
참여자 수12,301 명
중재(약물)Evolocumab
시작일2019년 6월 11일
완료일2025년 7월 25일
결과 공개일2026년 6월 25일

요약

This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event.

Number of Participants Who Experienced Coronary Heart Disease (CHD) Death, Myocardial Infarction (MI), or Ischemic Stroke, Whichever Occurred First

From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months · Participants

Placebo Q2W443 Participants
Evolocumab 140 mg Q2W336 Participants
p-value< 0.001
Hazard Ratio (HR)0.75 (95% CI 0.65–0.86)

Number of Participants Who Experienced CHD Death, MI, Ischemic Stroke, or Any Ischemia-driven Arterial Revascularization, Whichever Occurred First

From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months · Participants

Placebo Q2W907 Participants
Evolocumab 140 mg Q2W747 Participants
p-value< 0.001
Hazard Ratio (HR)0.81 (95% CI 0.73–0.89)

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