BENITIONSClinical Trial Intelligence

Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke

第3相 完了 NCT03872401

対象疾患Coronary Heart Disease
第3相
スポンサーAmgen
ステータス完了
参加者数12,301 名
介入(薬剤)Evolocumab
開始日2019年6月11日
完了日2025年7月25日
結果公開日2026年6月25日

概要

This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event.

Number of Participants Who Experienced Coronary Heart Disease (CHD) Death, Myocardial Infarction (MI), or Ischemic Stroke, Whichever Occurred First

From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months · Participants

Placebo Q2W443 Participants
Evolocumab 140 mg Q2W336 Participants
p-value< 0.001
Hazard Ratio (HR)0.75 (95% CI 0.65–0.86)

Number of Participants Who Experienced CHD Death, MI, Ischemic Stroke, or Any Ischemia-driven Arterial Revascularization, Whichever Occurred First

From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months · Participants

Placebo Q2W907 Participants
Evolocumab 140 mg Q2W747 Participants
p-value< 0.001
Hazard Ratio (HR)0.81 (95% CI 0.73–0.89)

BENITIONS で見る ClinicalTrials.gov の原文を見る

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このページは ClinicalTrials.gov の公開データをまとめたものです。医学的助言ではなく、投資助言でもありません。必ず専門医にご相談ください。