BMS-986205 and Nivolumab as First or Second Line Therapy in Treating Patients With Liver Cancer
1/2期
提前终止
NCT03695250
| 适应症 | Metastatic Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8, Stage IIIA Hepatocellular Carcinoma AJCC v8, Stage IIIB Hepatocellular Carcinoma AJCC v8 |
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| 分期 | 1/2期 |
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| 申办方 | Edward Kim |
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| 状态 | 提前终止 |
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| 受试者人数 | 8 人 |
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| 干预(药物) | IDO1 Inhibitor BMS-986205, Nivolumab |
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| 开始日期 | 2018年10月16日 |
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| 完成日期 | 2020年11月24日 |
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| 结果公布日 | 2023年8月22日 |
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摘要
This phase I/II trial studies the side effects and best dose of IDO1 inhibitor BMS-986205 (BMS-986205) when given together with nivolumab and how well it works as first or second line therapy in treating patients with liver cancer. BMS-986205 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as nivolumab, may interfere with the ability of tumor cells to grow and spread. Giving BMS-986205 and nivolumab may work better in treating patients with liver cancer.
Adverse Events (AE)
Up to 2 years. · participants
| Treatment (BMS-986205 and Nivolumab) | 2 participants |
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| Treatment (BMS-986205 and Nivolumab) | 1 participants |
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| Treatment (BMS-986205 and Nivolumab) | 1 participants |
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| Treatment (BMS-986205 and Nivolumab) | 1 participants |
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| Treatment (BMS-986205 and Nivolumab) | 1 participants |
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| Treatment (BMS-986205 and Nivolumab) | 1 participants |
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Objective Response Rate (ORR)
Up to approximately 2 years, 1 month. · percentage of participans
| Treatment (BMS-986205 and Nivolumab) | 12.5 percentage of participans |
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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。