Modulating Repetitive Negative Thinking Related Brain Networks in Young Adults With Depression
| Condition | Depressive Disorder, Major |
|---|---|
| Phase | N/A |
| Sponsor | Laureate Institute for Brain Research, Inc. |
| Status | Terminated |
| Enrollment | 54 participants |
| Interventions | Active neurofeedback, Sham neurofeedback |
| Start date | Jan 12, 2024 |
| Completion date | Apr 4, 2025 |
| Results posted | Jun 17, 2026 |
Summary
In this project, the investigators use real-time fMRI neurofeedback (rtfMRI-nf) to causally relate dysfunction of right anterior insula (rAI) and right superior temporal sulcus (rSTS) connectivity with the intensity of repetitive negative thinking (RNT). The investigators hypothesize that rtfMRI-nf reducing rAI-rSTS connectivity would reduce RNT. The investigators propose a randomized double-blind, sham-controlled trial of rtfMRI-nf with 110 young adults (n=55/arm) with major depressive disorder (MDD) and high trait-RNT levels.
Functional Connectivity Change Between Right Anterior Insular (rAI) and Right Superior Temporal Sulcus (rSTS) Within Visit1
| Active Neurofeedback | -0.1140 ± 0.0731 beta-value |
|---|---|
| Sham Neurofeedback | 0.5553 ± 0.1594 beta-value |
Open in BENITIONS View on ClinicalTrials.gov
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