Modulating Repetitive Negative Thinking Related Brain Networks in Young Adults With Depression
| 适应症 | Depressive Disorder, Major |
|---|---|
| 分期 | 不适用 |
| 申办方 | Laureate Institute for Brain Research, Inc. |
| 状态 | 提前终止 |
| 受试者人数 | 54 人 |
| 干预（药物） | Active neurofeedback, Sham neurofeedback |
| 开始日期 | 2024年1月12日 |
| 完成日期 | 2025年4月4日 |
| 结果公布日 | 2026年6月17日 |
摘要
In this project, the investigators use real-time fMRI neurofeedback (rtfMRI-nf) to causally relate dysfunction of right anterior insula (rAI) and right superior temporal sulcus (rSTS) connectivity with the intensity of repetitive negative thinking (RNT). The investigators hypothesize that rtfMRI-nf reducing rAI-rSTS connectivity would reduce RNT. The investigators propose a randomized double-blind, sham-controlled trial of rtfMRI-nf with 110 young adults (n=55/arm) with major depressive disorder (MDD) and high trait-RNT levels.
Functional Connectivity Change Between Right Anterior Insular (rAI) and Right Superior Temporal Sulcus (rSTS) Within Visit1
| Active Neurofeedback | -0.1140 ± 0.0731 beta-value |
|---|---|
| Sham Neurofeedback | 0.5553 ± 0.1594 beta-value |
在 BENITIONS 中查看 查看 ClinicalTrials.gov 原文
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