Modulating Repetitive Negative Thinking Related Brain Networks in Young Adults With Depression
| 대상 질환 | Depressive Disorder, Major |
|---|---|
| 임상 단계 | 단계 해당 없음 |
| 스폰서 | Laureate Institute for Brain Research, Inc. |
| 상태 | 조기 종료 |
| 참여자 수 | 54 명 |
| 중재(약물) | Active neurofeedback, Sham neurofeedback |
| 시작일 | 2024년 1월 12일 |
| 완료일 | 2025년 4월 4일 |
| 결과 공개일 | 2026년 6월 17일 |
요약
In this project, the investigators use real-time fMRI neurofeedback (rtfMRI-nf) to causally relate dysfunction of right anterior insula (rAI) and right superior temporal sulcus (rSTS) connectivity with the intensity of repetitive negative thinking (RNT). The investigators hypothesize that rtfMRI-nf reducing rAI-rSTS connectivity would reduce RNT. The investigators propose a randomized double-blind, sham-controlled trial of rtfMRI-nf with 110 young adults (n=55/arm) with major depressive disorder (MDD) and high trait-RNT levels.
Functional Connectivity Change Between Right Anterior Insular (rAI) and Right Superior Temporal Sulcus (rSTS) Within Visit1
| Active Neurofeedback | -0.1140 ± 0.0731 beta-value |
|---|---|
| Sham Neurofeedback | 0.5553 ± 0.1594 beta-value |
BENITIONS에서 보기 ClinicalTrials.gov 원문 보기
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