Severe Asthma, MepolizumaB and Affect: SAMBA Study
| Condition | Severe Eosinophilic Asthma, Psychological Distress, Anxiety, Depression |
|---|---|
| Phase | N/A |
| Sponsor | University Hospital Southampton NHS Foundation Trust |
| Status | Completed |
| Enrollment | 120 participants |
| Interventions | no study intervention. Patients receive standard clinical care |
| Start date | Sep 9, 2021 |
| Completion date | Mar 26, 2025 |
| Results posted | Jul 13, 2026 |
Summary
This is a real-life pragmatic non-randomised study to explore the impact of mepolizumab on the emotional and affective outcomes of patients with severe eosinophilic asthma and their partners. It will be conducted in two quantitative stages (Phases 1 and 2) with an additional third qualitative component (Phase 3).
Change in Emotional Composition (Using the Geneva Emotions Wheel)
| Patients With Severe Eosinophilic Asthma Phase 2 | 0.9 score |
|---|---|
| Partners of Patients With Severe Eosinophilic Asthma Phase 2 | 0.1 score |
| Patients With Severe Eosinophilic Asthma Phase 2 | 0.7 score |
| Partners of Patients With Severe Eosinophilic Asthma Phase 2 | 0.0 score |
| Patients With Severe Eosinophilic Asthma Phase 2 | 0.0 score |
| Partners of Patients With Severe Eosinophilic Asthma Phase 2 | 0.2 score |
Open in BENITIONS View on ClinicalTrials.gov
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