Effects of Chiropractic Care on Cytokine Levels in Multiple Sclerosis
Не применимо
Завершено
NCT04972929
| Заболевание | Multiple Sclerosis, Relapsing-Remitting |
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| Фаза | Не применимо |
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| Спонсор | University of Alabama at Birmingham |
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| Статус | Завершено |
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| Участники | 26 участн. |
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| Вмешательство | Spinal Manipulation, Sham Spinal Manipulation |
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| Дата начала | 15.09.2023 |
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| Дата завершения | 12.03.2025 |
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| Публикация результатов | 20.07.2026 |
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Кратко
Multiple sclerosis (MS) is an inflammatory autoimmune disease associated with an imbalance between pro- and anti-inflammatory markers (cytokines) resulting in a demyelinating and neurodegenerative disease. There is early evidence that spinal manipulation (chiropractic care) is better than control in influencing immune (cytokine) activity in asymptomatic participants, but few studies have been completed in participants with chronic inflammatory conditions, such as MS. The purpose of this project is to examine the immediate (after a single thoracic spinal manipulation treatment) and summative impact (after 8 thoracic spinal manipulation treatments occurring over 4 weeks) on pro-inflammatory (interleukin (IL) IL-1ß, IL-2, IL-6, Tumor necrosis factor-alpha) and anti-inflammatory (IL-4, IL-10) plasma cytokines 20 minutes and 2 hours after thoracic spinal manipulation in participants diagnosed with neuroinflammatory relapsing-remitting MS (RR-MS). Spinal manipulation treatment will be limited to the thoracic spine. Secondary outcomes will include determining the impact of 8 thoracic spinal manipulations on fatigue, cognitive processing speed, pain, depression, sleep, and motor function t
IL-6 Serum Inflammatory Cytokine Levels
From baseline to after 8th treatment at 4 weeks · pg/mL
| Spinal Manipulation/Trigger Point Therapy | 3.85 ± 6.01 pg/mL |
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| Sham-spinal Manipulation | 2.76 ± 4.77 pg/mL |
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| Mean Difference (Final Values) | -0.24 (95% CI -0.78–0.30) |
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IL-4 Serum Inflammatory Cytokine Levels
From baseline to after 8th treatment at 4 weeks · pg/ML
| Thoracic Spinal Manipulation/Trigger Point Therapy | 83.85 ± 187.51 pg/ML |
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| Sham-spinal Manipulation Group | 73.36 ± 198.60 pg/ML |
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| Mean Difference (Final Values) | -0.03 (95% CI -4.69–4.62) |
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IL-10 Serum Inflammatory Cytokine Levels
From baseline to after 8th treatment at 4 weeks · pg/ML
| Thoracic Spinal Manipulation/Trigger Point Therapy | 12.01 ± 25.01 pg/ML |
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| Sham-manipulation Group | 8.82 ± 17.14 pg/ML |
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| Mean Difference (Final Values) | 0.15 (95% CI -1.32–1.85) |
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