Effects of Chiropractic Care on Cytokine Levels in Multiple Sclerosis
不适用
已完成
NCT04972929
| 适应症 | Multiple Sclerosis, Relapsing-Remitting |
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| 分期 | 不适用 |
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| 申办方 | University of Alabama at Birmingham |
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| 状态 | 已完成 |
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| 受试者人数 | 26 人 |
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| 干预（药物） | Spinal Manipulation, Sham Spinal Manipulation |
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| 开始日期 | 2023年9月15日 |
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| 完成日期 | 2025年3月12日 |
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| 结果公布日 | 2026年7月20日 |
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摘要
Multiple sclerosis (MS) is an inflammatory autoimmune disease associated with an imbalance between pro- and anti-inflammatory markers (cytokines) resulting in a demyelinating and neurodegenerative disease. There is early evidence that spinal manipulation (chiropractic care) is better than control in influencing immune (cytokine) activity in asymptomatic participants, but few studies have been completed in participants with chronic inflammatory conditions, such as MS. The purpose of this project is to examine the immediate (after a single thoracic spinal manipulation treatment) and summative impact (after 8 thoracic spinal manipulation treatments occurring over 4 weeks) on pro-inflammatory (interleukin (IL) IL-1ß, IL-2, IL-6, Tumor necrosis factor-alpha) and anti-inflammatory (IL-4, IL-10) plasma cytokines 20 minutes and 2 hours after thoracic spinal manipulation in participants diagnosed with neuroinflammatory relapsing-remitting MS (RR-MS). Spinal manipulation treatment will be limited to the thoracic spine. Secondary outcomes will include determining the impact of 8 thoracic spinal manipulations on fatigue, cognitive processing speed, pain, depression, sleep, and motor function t
IL-6 Serum Inflammatory Cytokine Levels
From baseline to after 8th treatment at 4 weeks · pg/mL
| Spinal Manipulation/Trigger Point Therapy | 3.85 ± 6.01 pg/mL |
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| Sham-spinal Manipulation | 2.76 ± 4.77 pg/mL |
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| Mean Difference (Final Values) | -0.24 (95% CI -0.78–0.30) |
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IL-4 Serum Inflammatory Cytokine Levels
From baseline to after 8th treatment at 4 weeks · pg/ML
| Thoracic Spinal Manipulation/Trigger Point Therapy | 83.85 ± 187.51 pg/ML |
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| Sham-spinal Manipulation Group | 73.36 ± 198.60 pg/ML |
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| Mean Difference (Final Values) | -0.03 (95% CI -4.69–4.62) |
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IL-10 Serum Inflammatory Cytokine Levels
From baseline to after 8th treatment at 4 weeks · pg/ML
| Thoracic Spinal Manipulation/Trigger Point Therapy | 12.01 ± 25.01 pg/ML |
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| Sham-manipulation Group | 8.82 ± 17.14 pg/ML |
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| Mean Difference (Final Values) | 0.15 (95% CI -1.32–1.85) |
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本页整理自 ClinicalTrials.gov 的公开数据，不构成医疗建议，也不构成投资建议。请务必咨询专业医师。