Efficacy and Mechanism of Fecal Microbiota Transplantation of the Bai Ethnicity in the Treatment of UC
| 대상 질환 | Inflammatory Bowel Diseases |
|---|---|
| 임상 단계 | 단계 해당 없음 |
| 스폰서 | First Affiliated Hospital of Kunming Medical University |
| 상태 | 완료 |
| 참여자 수 | 102 명 |
| 중재(약물) | Fecal microbiota transplantation |
| 시작일 | 2024년 10월 14일 |
| 완료일 | 2025년 10월 20일 |
| 결과 공개일 | 2026년 6월 30일 |
요약
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), affects over 2 million people worldwide . Although biological therapies have significantly improved the treatment outcomes for UC, nearly two-thirds of patients experience diminishing drug responses over time, making it crucial to explore novel therapeutic approaches targeting the underlying pathophysiology of UC. UC is associated with alterations in gut microbiota, reduced microbial diversity, and changes in the relative abundance of dominant bacterial populations. Specifically, UC patients exhibit a marked decrease in gut microbiota diversity at the species level, with a reduction in Firmicutes (e.g., Clostridium butyricum) and an increase in Actinobacteria, Proteobacteria (e.g., Escherichia coli), Enterobacteriaceae, Streptococcus, and Bacteroides . Given the association between gut microbiota alterations and IBD activity, several studies have proposed microbiota-based therapies, particularly fecal microbiota transplantation (FMT), as a treatment for UC.
a Composite of Steroid-free Clinical Remission Together With Endoscopic Remission or Response
| the Bai Nationality-UC | 24 Participants |
|---|---|
| the Han Nationality-UC | 16 Participants |
BENITIONS에서 보기 ClinicalTrials.gov 원문 보기
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