Efficacy and Mechanism of Fecal Microbiota Transplantation of the Bai Ethnicity in the Treatment of UC
| 対象疾患 | Inflammatory Bowel Diseases |
|---|---|
| 相 | 該当なし |
| スポンサー | First Affiliated Hospital of Kunming Medical University |
| ステータス | 完了 |
| 参加者数 | 102 名 |
| 介入（薬剤） | Fecal microbiota transplantation |
| 開始日 | 2024年10月14日 |
| 完了日 | 2025年10月20日 |
| 結果公開日 | 2026年6月30日 |
概要
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), affects over 2 million people worldwide . Although biological therapies have significantly improved the treatment outcomes for UC, nearly two-thirds of patients experience diminishing drug responses over time, making it crucial to explore novel therapeutic approaches targeting the underlying pathophysiology of UC. UC is associated with alterations in gut microbiota, reduced microbial diversity, and changes in the relative abundance of dominant bacterial populations. Specifically, UC patients exhibit a marked decrease in gut microbiota diversity at the species level, with a reduction in Firmicutes (e.g., Clostridium butyricum) and an increase in Actinobacteria, Proteobacteria (e.g., Escherichia coli), Enterobacteriaceae, Streptococcus, and Bacteroides . Given the association between gut microbiota alterations and IBD activity, several studies have proposed microbiota-based therapies, particularly fecal microbiota transplantation (FMT), as a treatment for UC.
a Composite of Steroid-free Clinical Remission Together With Endoscopic Remission or Response
| the Bai Nationality-UC | 24 Participants |
|---|---|
| the Han Nationality-UC | 16 Participants |
BENITIONS で見る ClinicalTrials.gov の原文を見る
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