Telaglenastat Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung Cancer
| 대상 질환 | Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 |
|---|---|
| 임상 단계 | 1/2상 |
| 스폰서 | National Cancer Institute (NCI) |
| 상태 | 진행 중(모집 완료) |
| 참여자 수 | 22 명 |
| 중재(약물) | Biospecimen Collection, Computed Tomography, Magnetic Resonance Elastography, Osimertinib, Positron Emission Tomography |
| 시작일 | 2020년 3월 16일 |
| 완료일 | 2024년 6월 12일 |
| 결과 공개일 | 2025년 6월 19일 |
요약
This phase Ib trial studies the side effects and best dose of telaglenastat hydrochloride when given together with osimertinib in treating patients with stage IV non-small cell lung cancer and a mutation in the EGFR gene. Telaglenastat hydrochloride and osimertinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Recommended Phase II Dose (RP2D)
| Phase 1b Cohorts | 800 milligrams |
|---|---|
| Phase 1b Cohorts | 80 milligrams |
BENITIONS에서 보기 ClinicalTrials.gov 원문 보기
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