Telaglenastat Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung Cancer
| Condition | Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 |
|---|---|
| Phase | Phase 1/2 |
| Sponsor | National Cancer Institute (NCI) |
| Status | Active, not recruiting |
| Enrollment | 22 participants |
| Interventions | Biospecimen Collection, Computed Tomography, Magnetic Resonance Elastography, Osimertinib, Positron Emission Tomography |
| Start date | Mar 16, 2020 |
| Completion date | Jun 12, 2024 |
| Results posted | Jun 19, 2025 |
Summary
This phase Ib trial studies the side effects and best dose of telaglenastat hydrochloride when given together with osimertinib in treating patients with stage IV non-small cell lung cancer and a mutation in the EGFR gene. Telaglenastat hydrochloride and osimertinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Recommended Phase II Dose (RP2D)
| Phase 1b Cohorts | 800 milligrams |
|---|---|
| Phase 1b Cohorts | 80 milligrams |
Open in BENITIONS View on ClinicalTrials.gov
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- A Global Study to Assess the Effects of Osimertinib Following Chemoradiation in Patients W — AstraZeneca
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