Telaglenastat Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung Cancer
| Заболевание | Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 |
|---|---|
| Фаза | Фаза 1/2 |
| Спонсор | National Cancer Institute (NCI) |
| Статус | Идёт, набор закрыт |
| Участники | 22 участн. |
| Вмешательство | Biospecimen Collection, Computed Tomography, Magnetic Resonance Elastography, Osimertinib, Positron Emission Tomography |
| Дата начала | 16.03.2020 |
| Дата завершения | 12.06.2024 |
| Публикация результатов | 19.06.2025 |
Кратко
This phase Ib trial studies the side effects and best dose of telaglenastat hydrochloride when given together with osimertinib in treating patients with stage IV non-small cell lung cancer and a mutation in the EGFR gene. Telaglenastat hydrochloride and osimertinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Recommended Phase II Dose (RP2D)
| Phase 1b Cohorts | 800 milligrams |
|---|---|
| Phase 1b Cohorts | 80 milligrams |
Открыть в BENITIONS Открыть на ClinicalTrials.gov
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