The Impact of Ibutamoren on Nonalcoholic Fatty Liver Disease

2期 已完成 NCT05364684

摘要

Nonalcoholic fatty liver disease (NAFLD), fatty infiltration of the liver in the absence of alcohol use, is an increasingly recognized complication of obesity, with prevalence estimates of about 30% of individuals in the United States. A subset of these will develop progressive disease in the form of nonalcoholic steatohepatitis (NASH), which can progress to cirrhosis and liver failure. The investigators hypothesize that LUM-201 (Ibutamoren mesylate) will decrease intrahepatic lipid accumulation as quantified by proton magnetic resonance spectroscopy (1H-MRS).

Intrahepatic Lipid Content (IHL, Percent Liver Fat)

6 Months · absolute change in percentage liver fat

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