Pioglitazone to Reduce Sympathetic Overactivity in CKD Patients

4期 提前终止 NCT03471117

摘要

Chronic kidney disease (CKD) is associated with a higher risk of cardiovascular disease and death. An overactive sympathetic nervous system in CKD patients is one of the major mechanisms increasing the cardiovascular risks in this patient population. Recently, some studies have shown that a drug typically used to improve glucose control (pioglitazone) may also reduce sympathetic nerve activity and improve blood vessel function. The goal of this study is to determine whether a short-term treatment with pioglitazone can reduce sympathetic nerve impulses throughout the body in CKD patients.

Muscle Sympathetic Nerve Activity (MSNA)

1 month · MSNA burst frequency (bursts/min)

在 BENITIONS 中查看 查看 ClinicalTrials.gov 原文

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