Pioglitazone to Reduce Sympathetic Overactivity in CKD Patients
| Condition | Chronic Kidney Diseases |
|---|---|
| Phase | Phase 4 |
| Sponsor | The University of Texas at Arlington |
| Status | Terminated |
| Enrollment | 5 participants |
| Interventions | Pioglitazone |
| Start date | Apr 1, 2018 |
| Completion date | Jan 14, 2020 |
| Results posted | Jul 27, 2026 |
Summary
Chronic kidney disease (CKD) is associated with a higher risk of cardiovascular disease and death. An overactive sympathetic nervous system in CKD patients is one of the major mechanisms increasing the cardiovascular risks in this patient population. Recently, some studies have shown that a drug typically used to improve glucose control (pioglitazone) may also reduce sympathetic nerve activity and improve blood vessel function. The goal of this study is to determine whether a short-term treatment with pioglitazone can reduce sympathetic nerve impulses throughout the body in CKD patients.
Muscle Sympathetic Nerve Activity (MSNA)
| Pioglitazone | 43 ± 8 MSNA burst frequency (bursts/min) |
|---|---|
| Placebo | 41 ± 10 MSNA burst frequency (bursts/min) |
Open in BENITIONS View on ClinicalTrials.gov
Other trials for this condition
- A Community Health Worker Intervention to Address Adverse Pregnancy Outcomes — University of Alabama at Birmingham
- Improving Hypertension Medication Adherence for Older Adults — University of Arizona
- A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Ar — Actelion
- LiveSMART Trial to Prevent Falls in Patients With Cirrhosis — University of Michigan
- SPYRAL HTN-ON MED Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode R — Medtronic Vascular
- A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontro — AstraZeneca