BENITIONSClinical Trial Intelligence

ABC-lung: Atezolizumab, Bevacizumab and Chemotherapy in EGFR-mutant Non-small Cell Lung Carcinoma

Phase 2 Completed NCT04245085

ConditionEGFRmutant Stage IIIB/C or IV Non-squamous NSCLC
PhasePhase 2
SponsorETOP IBCSG Partners Foundation
StatusCompleted
Enrollment95 participants
InterventionsAtezolizumab, Bevacizumab, Carboplatin, Paclitaxel, Pemetrexed
Start dateSep 29, 2020
Completion dateJul 22, 2024
Results postedMay 12, 2026

Summary

ETOP 15-19 ABC-lung is an international, multi-centre open-label, randomized phase II trial with two non-comparative parallel arms of atezolizumab plus bevacizumab with carboplatin-paclitaxel (Arm A) or atezolizumab, bevacizumab and pemetrexed (Arm B) in patients with stage IIIB-IV non-squamous non-small cell lung cancer (NSCLC) harbouring EGFR mutations after failure of standard EGFR tyrosine kinase inhibitors (TKIs).

Progression-Free Survival (PFS) Rate at 12-months

From randomization to 12 months; participants assessed for progression-free survival status at 12 months. · Participants

Arm A9 Participants
Arm B11 Participants
p-value0.367
proportion20.9 (95% CI 10.0–36.0)

Open in BENITIONS View on ClinicalTrials.gov

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