ABC-lung: Atezolizumab, Bevacizumab and Chemotherapy in EGFR-mutant Non-small Cell Lung Carcinoma
Phase 2
Completed
NCT04245085
| Condition | EGFRmutant Stage IIIB/C or IV Non-squamous NSCLC |
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| Phase | Phase 2 |
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| Sponsor | ETOP IBCSG Partners Foundation |
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| Status | Completed |
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| Enrollment | 95 participants |
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| Interventions | Atezolizumab, Bevacizumab, Carboplatin, Paclitaxel, Pemetrexed |
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| Start date | Sep 29, 2020 |
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| Completion date | Jul 22, 2024 |
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| Results posted | May 12, 2026 |
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Summary
ETOP 15-19 ABC-lung is an international, multi-centre open-label, randomized phase II trial with two non-comparative parallel arms of atezolizumab plus bevacizumab with carboplatin-paclitaxel (Arm A) or atezolizumab, bevacizumab and pemetrexed (Arm B) in patients with stage IIIB-IV non-squamous non-small cell lung cancer (NSCLC) harbouring EGFR mutations after failure of standard EGFR tyrosine kinase inhibitors (TKIs).
Progression-Free Survival (PFS) Rate at 12-months
From randomization to 12 months; participants assessed for progression-free survival status at 12 months. · Participants
| Arm A | 9 Participants |
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| Arm B | 11 Participants |
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| p-value | 0.367 |
| proportion | 20.9 (95% CI 10.0–36.0) |
Open in BENITIONS
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