BENITIONSClinical Trial Intelligence

Coformulation of Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab (MK-3475) Monotherapy for Programmed Cell Death 1 Ligand 1 (PD-L1) Positive Metastatic Non-Small Cell Lung Cancer (MK-7684A-003, KEYVIBE-003)

Фаза 3 Завершено NCT04738487

ЗаболеваниеLung Neoplasms, Non-Small-Cell Lung Carcinoma
ФазаФаза 3
СпонсорMerck Sharp & Dohme LLC
СтатусЗавершено
Участники1,264 участн.
ВмешательствоPembrolizumab/Vibostolimab, Pembrolizumab
Дата начала7.04.2021
Дата завершения5.09.2024
Публикация результатов26.08.2025

Кратко

Researchers are looking for new ways to treat people with metastatic non-small cell lung cancer (NSCLC) that is PD-L1 positive. * Metastatic means cancer that has spread to other parts of the body. * PD-L1 positive means that PD-L1 is found on the cancer cells. PD-L1 is a protein that can help the cancer hide from the body's immune system. The goal of this study is to learn if people who receive vibostolimab and pembrolizumab live longer overall and without the cancer getting worse than people who receive pembrolizumab alone.

Overall Survival (OS) in Participants With PD-L1 TPS ≥50%

Up to ~39 months · Months

Pembrolizumab/Vibostolimab15.7 Months
Pembrolizumab20.3 Months
p-value0.6712
Hazard Ratio (HR)1.06 (95% CI 0.83–1.35)

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