Coformulation of Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab (MK-3475) Monotherapy for Programmed Cell Death 1 Ligand 1 (PD-L1) Positive Metastatic Non-Small Cell Lung Cancer (MK-7684A-003, KEYVIBE-003)
Фаза 3
Завершено
NCT04738487
| Заболевание | Lung Neoplasms, Non-Small-Cell Lung Carcinoma |
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| Фаза | Фаза 3 |
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| Спонсор | Merck Sharp & Dohme LLC |
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| Статус | Завершено |
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| Участники | 1,264 участн. |
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| Вмешательство | Pembrolizumab/Vibostolimab, Pembrolizumab |
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| Дата начала | 7.04.2021 |
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| Дата завершения | 5.09.2024 |
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| Публикация результатов | 26.08.2025 |
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Кратко
Researchers are looking for new ways to treat people with metastatic non-small cell lung cancer (NSCLC) that is PD-L1 positive. * Metastatic means cancer that has spread to other parts of the body. * PD-L1 positive means that PD-L1 is found on the cancer cells. PD-L1 is a protein that can help the cancer hide from the body's immune system. The goal of this study is to learn if people who receive vibostolimab and pembrolizumab live longer overall and without the cancer getting worse than people who receive pembrolizumab alone.
Overall Survival (OS) in Participants With PD-L1 TPS ≥50%
Up to ~39 months · Months
| Pembrolizumab/Vibostolimab | 15.7 Months |
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| Pembrolizumab | 20.3 Months |
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| p-value | 0.6712 |
| Hazard Ratio (HR) | 1.06 (95% CI 0.83–1.35) |
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