Coformulation of Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab (MK-3475) Monotherapy for Programmed Cell Death 1 Ligand 1 (PD-L1) Positive Metastatic Non-Small Cell Lung Cancer (MK-7684A-003, KEYVIBE-003)
第3相
完了
NCT04738487
| 対象疾患 | Lung Neoplasms, Non-Small-Cell Lung Carcinoma |
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| 相 | 第3相 |
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| スポンサー | Merck Sharp & Dohme LLC |
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| ステータス | 完了 |
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| 参加者数 | 1,264 名 |
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| 介入(薬剤) | Pembrolizumab/Vibostolimab, Pembrolizumab |
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| 開始日 | 2021年4月7日 |
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| 完了日 | 2024年9月5日 |
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| 結果公開日 | 2025年8月26日 |
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概要
Researchers are looking for new ways to treat people with metastatic non-small cell lung cancer (NSCLC) that is PD-L1 positive. * Metastatic means cancer that has spread to other parts of the body. * PD-L1 positive means that PD-L1 is found on the cancer cells. PD-L1 is a protein that can help the cancer hide from the body's immune system. The goal of this study is to learn if people who receive vibostolimab and pembrolizumab live longer overall and without the cancer getting worse than people who receive pembrolizumab alone.
Overall Survival (OS) in Participants With PD-L1 TPS ≥50%
Up to ~39 months · Months
| Pembrolizumab/Vibostolimab | 15.7 Months |
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| Pembrolizumab | 20.3 Months |
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| p-value | 0.6712 |
| Hazard Ratio (HR) | 1.06 (95% CI 0.83–1.35) |
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