BENITIONSClinical Trial Intelligence

Coformulation of Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab (MK-3475) Monotherapy for Programmed Cell Death 1 Ligand 1 (PD-L1) Positive Metastatic Non-Small Cell Lung Cancer (MK-7684A-003, KEYVIBE-003)

第3相 完了 NCT04738487

対象疾患Lung Neoplasms, Non-Small-Cell Lung Carcinoma
第3相
スポンサーMerck Sharp & Dohme LLC
ステータス完了
参加者数1,264 名
介入(薬剤)Pembrolizumab/Vibostolimab, Pembrolizumab
開始日2021年4月7日
完了日2024年9月5日
結果公開日2025年8月26日

概要

Researchers are looking for new ways to treat people with metastatic non-small cell lung cancer (NSCLC) that is PD-L1 positive. * Metastatic means cancer that has spread to other parts of the body. * PD-L1 positive means that PD-L1 is found on the cancer cells. PD-L1 is a protein that can help the cancer hide from the body's immune system. The goal of this study is to learn if people who receive vibostolimab and pembrolizumab live longer overall and without the cancer getting worse than people who receive pembrolizumab alone.

Overall Survival (OS) in Participants With PD-L1 TPS ≥50%

Up to ~39 months · Months

Pembrolizumab/Vibostolimab15.7 Months
Pembrolizumab20.3 Months
p-value0.6712
Hazard Ratio (HR)1.06 (95% CI 0.83–1.35)

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このページは ClinicalTrials.gov の公開データをまとめたものです。医学的助言ではなく、投資助言でもありません。必ず専門医にご相談ください。