BENITIONSClinical Trial Intelligence

Coformulation of Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab (MK-3475) Monotherapy for Programmed Cell Death 1 Ligand 1 (PD-L1) Positive Metastatic Non-Small Cell Lung Cancer (MK-7684A-003, KEYVIBE-003)

3期 已完成 NCT04738487

适应症Lung Neoplasms, Non-Small-Cell Lung Carcinoma
分期3期
申办方Merck Sharp & Dohme LLC
状态已完成
受试者人数1,264 人
干预(药物)Pembrolizumab/Vibostolimab, Pembrolizumab
开始日期2021年4月7日
完成日期2024年9月5日
结果公布日2025年8月26日

摘要

Researchers are looking for new ways to treat people with metastatic non-small cell lung cancer (NSCLC) that is PD-L1 positive. * Metastatic means cancer that has spread to other parts of the body. * PD-L1 positive means that PD-L1 is found on the cancer cells. PD-L1 is a protein that can help the cancer hide from the body's immune system. The goal of this study is to learn if people who receive vibostolimab and pembrolizumab live longer overall and without the cancer getting worse than people who receive pembrolizumab alone.

Overall Survival (OS) in Participants With PD-L1 TPS ≥50%

Up to ~39 months · Months

Pembrolizumab/Vibostolimab15.7 Months
Pembrolizumab20.3 Months
p-value0.6712
Hazard Ratio (HR)1.06 (95% CI 0.83–1.35)

在 BENITIONS 中查看 查看 ClinicalTrials.gov 原文

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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。