Coformulation of Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab (MK-3475) Monotherapy for Programmed Cell Death 1 Ligand 1 (PD-L1) Positive Metastatic Non-Small Cell Lung Cancer (MK-7684A-003, KEYVIBE-003)
3期
已完成
NCT04738487
| 适应症 | Lung Neoplasms, Non-Small-Cell Lung Carcinoma |
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| 分期 | 3期 |
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| 申办方 | Merck Sharp & Dohme LLC |
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| 状态 | 已完成 |
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| 受试者人数 | 1,264 人 |
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| 干预(药物) | Pembrolizumab/Vibostolimab, Pembrolizumab |
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| 开始日期 | 2021年4月7日 |
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| 完成日期 | 2024年9月5日 |
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| 结果公布日 | 2025年8月26日 |
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摘要
Researchers are looking for new ways to treat people with metastatic non-small cell lung cancer (NSCLC) that is PD-L1 positive. * Metastatic means cancer that has spread to other parts of the body. * PD-L1 positive means that PD-L1 is found on the cancer cells. PD-L1 is a protein that can help the cancer hide from the body's immune system. The goal of this study is to learn if people who receive vibostolimab and pembrolizumab live longer overall and without the cancer getting worse than people who receive pembrolizumab alone.
Overall Survival (OS) in Participants With PD-L1 TPS ≥50%
Up to ~39 months · Months
| Pembrolizumab/Vibostolimab | 15.7 Months |
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| Pembrolizumab | 20.3 Months |
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| p-value | 0.6712 |
| Hazard Ratio (HR) | 1.06 (95% CI 0.83–1.35) |
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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。