Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD
| 대상 질환 | Treatment Resistant Major Depressive Disorder |
|---|---|
| 임상 단계 | 4상 |
| 스폰서 | Massachusetts General Hospital |
| 상태 | 완료 |
| 참여자 수 | 278 명 |
| 중재(약물) | Aripiprazole, Repetitive transcranial magnetic stimulation (rTMS), Venlafaxine XR |
| 시작일 | 2017년 7월 13일 |
| 완료일 | 2022년 4월 24일 |
| 결과 공개일 | 2026년 7월 9일 |
요약
This is a multi-site, randomized, open-label, effectiveness trial comparing three treatment arms for Major Depressive Disorder (MDD) patients with TRD who are currently on ongoing, stable and adequate antidepressant therapy (ADT). Adequate ADT is defined as a therapeutically sufficient dose for a sufficient treatment period, which would be expected to be effective as listed in the MGH Antidepressant Treatment Response Questionnaire (ATRQ). Patients will be randomized in a 1:1:1 fashion to one of three open-label treatment arms: a) aripiprazole augmentation, b) rTMS augmentation, and c) switching to venlafaxine XR or Duloxetine.
Montgomery-Asberg Depression Rating Scale (MADRS)
| Aripiprazole Augmentation | -14.9 ± 1.1 points |
|---|---|
| rTMS Augmentation | -17.39 ± 1.3 points |
| Switch to Venlafaxine XR/Duloxetine | -13.22 ± 1.1 points |
BENITIONS에서 보기 ClinicalTrials.gov 원문 보기
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