BENITIONSClinical Trial Intelligence

Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer

2상 진행 중(모집 완료) NCT02888743

대상 질환Metastatic Colorectal Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Stage IV Colorectal Cancer AJCC v7, Stage IV Lung Non-Small Cell Cancer AJCC v7
임상 단계2상
스폰서National Cancer Institute (NCI)
상태진행 중(모집 완료)
참여자 수110 명
중재(약물)Durvalumab, Radiation Therapy, Tremelimumab
시작일2017년 8월 14일
완료일2023년 12월 31일
결과 공개일2024년 6월 25일

요약

This randomized phase II trial studies the side effects of durvalumab and tremelimumab and to see how well they work with or without high or low-dose radiation therapy in treating patients with colorectal or non-small cell lung cancer that has spread to other parts of the body (metastatic). Immunotherapy with durvalumab and tremelimumab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving durvalumab and tremelimumab with radiation therapy may work better in treating patients with colorectal or non-small cell lung cancer.

Overall Response Rate

Up to 2 years · Participants

NSCLC Arm A (Tremelimumab, Durvalumab, HD-RT)3 Participants
NSCLC Arm B (Tremelimumab, Durvalumab, LD-RT)2 Participants
NSCLC Arm C (Tremelimumab, Durvalumab)3 Participants
CRC Arm A (Tremelimumab, Durvalumab, HD-RT)0 Participants
CRC Arm B (Tremelimumab, Durvalumab, LD-RT)0 Participants
p-value0.99
Difference between proportions0.0 (95% CI -14.6–14.6)

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