Octreotide Acetate and Recombinant Interferon Alfa-2b or Bevacizumab in Treating Patients With Metastatic or Locally Advanced, High-Risk Neuroendocrine Tumor
3상
진행 중(모집 완료)
NCT00569127
| 대상 질환 | Colorectal Neuroendocrine Tumor G1, Gastric Neuroendocrine Tumor G1, Neuroendocrine Neoplasm, Neuroendocrine Tumor |
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| 임상 단계 | 3상 |
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| 스폰서 | National Cancer Institute (NCI) |
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| 상태 | 진행 중(모집 완료) |
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| 참여자 수 | 427 명 |
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| 중재(약물) | Bevacizumab, Laboratory Biomarker Analysis, Octreotide Acetate, Recombinant Interferon Alfa-2b |
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| 시작일 | 2007년 12월 1일 |
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| 완료일 | 2015년 1월 1일 |
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| 결과 공개일 | 2016년 4월 28일 |
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요약
This randomized phase III trial studies octreotide acetate and recombinant interferon alfa-2b to see how well it works compared to octreotide acetate and bevacizumab in treating patients with high-risk neuroendocrine tumors that have spread to other places in the body (metastatic) or spread from where it started to nearby tissue or lymph nodes (locally advanced). Octreotide acetate and recombinant interferon alfa-2b may interfere with the growth of tumor cells and slow the growth of cancer. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. It is not yet known whether giving octreotide acetate together with recombinant interferon alfa-2b is more effective than giving octreotide acetate together with bevacizumab in treating patients with neuroendocrine tumor.
Central Review-based Progression-Free Survival
Up to 3 years · months
| Octreotide, Bevacizumab | 16.6 months |
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| Octreotide, Interferon Alpha-2b | 15.4 months |
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| p-value | 0.55 |
| Hazard Ratio (HR) | 0.93 (95% CI 0.73–1.18) |
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