Specific Electrophenotypes in Atrial Fibrillation
| 适应症 | Atrial Fibrillation |
|---|---|
| 分期 | 不适用 |
| 申办方 | Imperial College London |
| 状态 | 提前终止 |
| 受试者人数 | 1 人 |
| 干预（药物） | Biomarkers, electrocardiographic imaging, intracardiac electrograms, cardiac magnetic resonance imaging |
| 开始日期 | 2022年5月19日 |
| 完成日期 | 2024年8月27日 |
| 结果公布日 | 2026年3月12日 |
摘要
This study will investigate a common heart rhythm disturbance (arrhythmia), atrial fibrillation (AF), to improve understanding of how best to treat it in different patients. Direct current cardioversion (DCCV) is a procedure that can revert the heart to a normal rhythm, however almost all patients will only have a transient benefit, and their heart will return to the abnormal rhythm, AF. Ablation is an invasive procedure that creates scar tissue within the heart to reduce the arrhythmias, with a longer lasting effect than DCCV. It has been used with success in AF that occurs occasionally (paroxysmal) but is not as effective in AF that is more long-lasting, also known as persistent AF. Persistent AF is major cause of symptoms of breathlessness and palpitations and significantly increases the risk of stroke. Doctors are unable to accurately predict which patients will benefit most from an ablation, this can lead to as many as 50% of patients not benefitting from the procedure. The aim is to better predict which patients will benefit from an ablation. The study will include patients undergoing AF ablation or DCCV and perform additional tests including blood tests a heart MRI scan, a s
Freedom From Atrial Fibrillation
在 BENITIONS 中查看 查看 ClinicalTrials.gov 原文
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