BENITIONSClinical Trial Intelligence

Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).

2期 进行中(已停止招募) NCT04895722

适应症Colorectal Cancer
分期2期
申办方Merck Sharp & Dohme LLC
状态进行中(已停止招募)
受试者人数302 人
干预(药物)Pembrolizumab, Pembrolizumab/Quavonlimab, Pembrolizumab/Favezelimab, Pembrolizumab/Vibostolimab, MK-4830
开始日期2021年6月25日
完成日期2025年5月21日
结果公布日2026年6月8日

摘要

The purpose of this study is to assess the efficacy and safety of co-formulated pembrolizumab/quavonlimab versus other treatments in participants with MSI-H or dMMR Metastatic Stage IV Colorectal Cancer.

Objective Response Rate (ORR) Per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as Assessed by Blinded Independent Central Review (BICR)

Up to approximately 46 months · Percentage of Participants

Cohort A - Pembrolizumab/Quavonlimab45.0 Percentage of Participants
Cohort A - Pembrolizumab29.5 Percentage of Participants
Cohort B - Pembrolizumab/Quavonlimab46.2 Percentage of Participants
Cohort B - Pembrolizumab Plus MK-483065.0 Percentage of Participants
Cohort B - Pembrolizumab/Favezelimab37.5 Percentage of Participants
Cohort B - Pembrolizumab/Vibostolimab48.8 Percentage of Participants
Difference in Percentage15.6 (95% CI -1.7–32.1)

在 BENITIONS 中查看 查看 ClinicalTrials.gov 原文

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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。