BENITIONSClinical Trial Intelligence

Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).

第2相 実施中(募集終了) NCT04895722

対象疾患Colorectal Cancer
第2相
スポンサーMerck Sharp & Dohme LLC
ステータス実施中(募集終了)
参加者数302 名
介入(薬剤)Pembrolizumab, Pembrolizumab/Quavonlimab, Pembrolizumab/Favezelimab, Pembrolizumab/Vibostolimab, MK-4830
開始日2021年6月25日
完了日2025年5月21日
結果公開日2026年6月8日

概要

The purpose of this study is to assess the efficacy and safety of co-formulated pembrolizumab/quavonlimab versus other treatments in participants with MSI-H or dMMR Metastatic Stage IV Colorectal Cancer.

Objective Response Rate (ORR) Per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as Assessed by Blinded Independent Central Review (BICR)

Up to approximately 46 months · Percentage of Participants

Cohort A - Pembrolizumab/Quavonlimab45.0 Percentage of Participants
Cohort A - Pembrolizumab29.5 Percentage of Participants
Cohort B - Pembrolizumab/Quavonlimab46.2 Percentage of Participants
Cohort B - Pembrolizumab Plus MK-483065.0 Percentage of Participants
Cohort B - Pembrolizumab/Favezelimab37.5 Percentage of Participants
Cohort B - Pembrolizumab/Vibostolimab48.8 Percentage of Participants
Difference in Percentage15.6 (95% CI -1.7–32.1)

BENITIONS で見る ClinicalTrials.gov の原文を見る

同じ疾患の他の治験

すべての治験

このページは ClinicalTrials.gov の公開データをまとめたものです。医学的助言ではなく、投資助言でもありません。必ず専門医にご相談ください。