BENITIONSClinical Trial Intelligence

A Study to Compare the Administration of Pembrolizumab After Surgery Versus Administration Both Before and After Surgery for High-Risk Melanoma

2期 进行中(已停止招募) NCT03698019

适应症Acral Lentiginous Melanoma, Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8, Mucosal Melanoma
分期2期
申办方National Cancer Institute (NCI)
状态进行中(已停止招募)
受试者人数313 人
干预(药物)Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging, Pembrolizumab, Therapeutic Conventional Surgery
开始日期2019年2月15日
完成日期2022年9月1日
结果公布日2023年11月21日

摘要

This phase II trial studies how pembrolizumab works before and after surgery in treating patients with stage III-IV high-risk melanoma. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving pembrolizumab before and after surgery may work better compared to after surgery alone in treating melanoma.

Two-Year Event-Free Survival Rate

2 years · percentage of participants

Arm I (Adjuvant Pembrolizumab)49 percentage of participants
Arm II (Adjuvant and Neoadjuvant Pembrolizumab)72 percentage of participants
p-value0.004
Hazard Ratio (HR)0.64

在 BENITIONS 中查看 查看 ClinicalTrials.gov 原文

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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。